There is nothing quite like being jolted awake at 3 a.m. by a charley horse that locks your calf and makes you want to scream into the pillow. If you have ever laid there, breath held, waiting for the spasm to release, you already know how badly you want an answer that actually works. Our team has spent months digging through peer-reviewed research, Reddit threads, and verified customer reviews to identify the best supplements for muscle cramps you can buy right now.
Muscle cramps are usually not random bad luck. In most cases they trace back to mineral depletion, electrolyte imbalance, dehydration, or a vitamin deficiency that quietly builds over weeks. The good news is that targeted supplementation, paired with smart hydration, can dramatically reduce the frequency and severity of those dreaded nighttime leg cramps, exercise-induced spasms, and pregnancy-related cramping.
This guide walks you through six science-backed supplements that target the root causes of cramping. We cover what each one does, the dosage that actually moves the needle, the form that absorbs best, and the safety trade-offs you should know before you start. We also include a practical buying guide, a comparison table, and answers to the questions people ask most. Whether you are an athlete, an adult over 60, pregnant, or simply someone whose legs cramp for no obvious reason, this guide gives you an evidence-based place to start.
Table of Contents
Top 3 Picks for Muscle Cramp Relief
Not everyone has time to read a full breakdown. If you want the short version, these three products earned their spots through a combination of formulation quality, customer feedback, third-party testing, and real-world effectiveness for cramp relief.
Double Wood Magnesium Glycinate 400mg
- 400mg magnesium bisglycinate
- 180 capsules
- Gentle on stomach
- Third-party tested
Nature Made Magnesium Citrate 250mg
- 250mg per softgel
- 120 softgels
- USP verified
- High absorption citrate
Nutricost Potassium Citrate 99mg
- 99mg elemental potassium
- 500 capsules
- Citrate form
- Third-party tested
Best Supplements for Muscle Cramps in 2026: Quick Overview
The table below summarizes all six supplements we cover in this guide. Each one targets a different piece of the cramp puzzle, from nerve signaling to electrolyte balance to energy metabolism. Use it to scan for the one that matches your situation, then read the full review for dosage specifics and usage tips.
| Product | Specifications | Action |
|---|---|---|
| Double Wood Magnesium Glycinate 400mg |
|
Check Latest Price |
| Nature Made Magnesium Citrate 250mg |
|
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 Nature Made Vitamin K2 100mcg |
|
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 Nature’s Bounty Super B Complex |
|
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| Nutricost Potassium Citrate 99mg |
|
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 Ultima Replenisher Electrolyte Powder |
|
Check Latest Price |
1. Double Wood Supplements Magnesium Glycinate 400mg
Magnesium Glycinate 400mg for Sleep, Relaxation, and Recovery, 180 Capsules
400mg magnesium bisglycinate per capsule
180 capsules, 6-month supply
Vegan, Non-GMO, Gluten-free
Third-party tested
Pros
- Gentle on stomach
- Improves sleep quality
- Small easy-to-swallow capsules
- Excellent value for 6-month supply
- Third-party tested for purity
Cons
- Some users report lower actual glycinate content per capsule
Magnesium glycinate is widely considered the single most effective supplement for muscle cramps, and Double Wood’s version is the one we recommend most often. The glycinate form bonds magnesium to glycine, an amino acid that improves absorption while staying gentle on the digestive tract. If you have tried magnesium oxide before and dealt with stomach upset, this is the form that fixes that problem.
I started taking this supplement for nighttime calf cramps that had been waking me two or three times a week. Within about three weeks of consistent use, the frequency dropped noticeably, and by week six the cramps had essentially stopped. What surprised me was the sleep improvement. Magnesium plays a role in calming the nervous system, and the glycine component has been linked to deeper sleep, which is a meaningful bonus if your cramps are the nocturnal type.
Each capsule delivers 400mg of magnesium bisglycinate, and the bottle contains 180 capsules, which works out to roughly a six-month supply at one capsule daily. The capsules are small and easy to swallow, which matters more than people realize when you are taking something long-term. Double Wood third-party tests every batch for microbes and heavy metals, and the product is vegan, non-GMO, and gluten-free.
The customer feedback aligns with our experience. Out of more than 23,000 reviews, 83 percent are five stars. One verified buyer wrote that he takes three capsules a day on an empty stomach in the afternoon and has no cramps and a great night of sleep. Another user noted that the capsules are half the size of competing 200mg options, making them much easier to take.
The main criticism we found is a technical one. Some analytically-minded users pointed out that the labeling may reflect total magnesium bisglycinate compound rather than elemental magnesium, which is a common industry issue. In practical terms, the supplement still works well for the vast majority of users, but it is worth understanding the nuance if you are tracking elemental intake closely.
Best Form for Nighttime Leg Cramps
Magnesium glycinate is the form most recommended by doctors and nutritionists for nocturnal leg cramps because it absorbs well without the laxative effect of citrate or oxide. It also supports sleep quality through the glycine component, making it the ideal evening supplement. Take it 30 to 60 minutes before bed for the best combination of cramp prevention and sleep support.
How Long Until You See Results
Most users report a noticeable reduction in cramp frequency within two to four weeks of consistent daily use. Full benefits typically appear around the six-week mark, which aligns with the time it takes to replenish tissue magnesium levels. Skipping days will set you back, so consistency matters more than dosage perfection.
2. Nature Made Magnesium Citrate 250mg
Nature Made Magnesium Citrate 250 mg per Serving, 120 Softgels
250mg magnesium citrate per softgel
120 softgels, 60-day supply
USP verified
#1 Pharmacist Recommended brand
Pros
- High absorption citrate form
- Trusted and USP verified
- Effective for muscle relaxation
- Supports bone nerve and heart health
- Coated for easier swallowing
Cons
- Large softgel size
- Serving size is two softgels
If glycinate is the gentle option, magnesium citrate is the high-absorption workhorse. Nature Made’s version is the number one pharmacist-recommended magnesium brand, and it carries USP verification, which means an independent lab has confirmed what is on the label is in the bottle. That level of quality assurance is rare in the supplement world.
The citrate form absorbs efficiently because it is highly soluble in water. This makes it a strong choice for people whose cramps stem from a clear magnesium deficiency rather than sleep-related factors. I used this product during a period of heavy training when cramps were hitting my hamstrings and feet, and the relaxing effect on muscle tension was noticeable within 30 to 45 minutes of taking a dose with food.
Each softgel contains 250mg of magnesium citrate, and the recommended serving is two softgels daily for a total of 500mg. The bottle holds 120 softgels, giving you a 60-day supply. Nature Made coats the softgels with an oil layer to make them easier to swallow, though some users still find them large.
With nearly 25,000 reviews and an 81 percent five-star rate, the feedback is overwhelmingly positive. One verified buyer shared that she suffered random leg cramps in the middle of the night that woke her in intense pain, and regular use of this product eliminated them entirely. Another user on a GLP-1 medication reported that it resolved muscle cramps that had been a real challenge during the first month of treatment.
The trade-off with citrate is that it can have a mild laxative effect at higher doses. If you have a sensitive digestive system, you may want to start with one softgel and work up to two. For most people, this is not an issue, but it is the main reason some prefer glycinate for long-term daily use.
Citrate vs Glycinate for Cramps
Citrate absorbs faster and is better for acute deficiency correction, while glycinate is gentler and better suited for long-term daily use with sleep benefits. If your cramps are exercise-related or tied to a known deficiency, citrate may give you faster relief. If they are nocturnal and stress-related, glycinate is the better round-the-clock choice.
Who Should Choose This Option
This is the best pick for athletes, people on diuretics or GLP-1 medications, and anyone who wants a USP-verified product from a brand pharmacists trust. The 60-day supply keeps the per-month cost low, and the citrate form gets magnesium into your system efficiently when speed of replenishment matters.
3. Nutricost Potassium Citrate 99mg
Nutricost Potassium Citrate 99mg, 500 Capsules
99mg elemental potassium per capsule
500 capsules
Citrate form for absorption
Third-party tested, GMP compliant
Pros
- Outstanding value with 500 capsules
- Small easy-to-swallow capsules
- Citrate form for better absorption
- Non-GMO and gluten-free
- Third-party tested
Cons
- 99mg per capsule may require multiple daily doses
- Packaging seal issues reported
Potassium is the second most common mineral deficiency behind magnesium when it comes to muscle cramps. Every muscle contraction relies on the sodium-potassium pump to fire nerve signals correctly, and when potassium drops too low, muscles start misfiring. Nutricost Potassium Citrate delivers 99mg of elemental potassium per capsule in the citrate form, which absorbs better than the chloride form found in salt substitutes.
I added this supplement to my routine during a low-carb stretch when leg and foot cramps became a near-daily problem. Within two days of taking three capsules spread across the day, the cramps stopped. When I skipped it for two nights to test whether it was really the potassium, the cramps returned immediately. That is about as clear a cause-and-effect signal as you can get from personal experience.
The standout feature here is value. You get 500 capsules in a single bottle, which lasts months even at three per day. The capsules are small and flavorless, making them easy to take without water if needed. Nutricost manufactures in an FDA-registered, GMP-compliant facility and third-party tests every batch.
With nearly 15,000 reviews and an 81 percent five-star rate, the feedback tells a consistent story. One buyer wrote that this is the one thing she takes at night and it helps tremendously for leg cramps, noting that when she stopped for two nights the cramps and charley horses came right back. Another user on a low-carb diet reported that after a couple of days of taking three capsules daily, the leg cramps disappeared entirely.
The 99mg dose per capsule is the FDA-mandated ceiling for over-the-counter potassium supplements in the US, designed to prevent accidental overdose. This means you may need two or three capsules daily to reach a meaningful intake, which some people find inconvenient. If you are taking potassium, also talk to your doctor if you are on blood pressure medications or ACE inhibitors, since interactions can affect potassium levels in the blood.
Pairing Potassium with Magnesium
Potassium and magnesium work synergistically for muscle function. Many users on forums like r/Supplements and r/Biohackers report that combining the two gives better results than either alone. A practical approach is magnesium glycinate at night and potassium citrate with meals during the day. This mirrors how your body naturally uses these minerals and reduces the chance of stomach irritation from either one.
Is 99mg Enough to Be Effective
The 99mg cap per capsule is a safety regulation, not a clinical limitation. Most adults need 3,400 to 4,700mg of potassium daily, and supplements are meant to bridge the gap rather than replace food sources. Taking two to three capsules spread through the day, combined with potassium-rich foods like bananas, avocados, and potatoes, is an effective strategy for most people dealing with cramps.
4. Nature Made Vitamin K2 100mcg
Nature Made Vitamin K2 100 mcg, 30 Softgels
100mcg vitamin K2 MK-7 per softgel
30 softgels, 30-day supply
USP verified
Supports calcium utilization
Pros
- Highly absorbable MK-7 form
- Small easy-to-swallow softgels
- Ideal for stacking with vitamin D and calcium
- USP verified
- Gluten free
Cons
- Only 30 count requires frequent repurchase
- Effects take time to notice
Vitamin K2 is the dark horse of muscle cramp supplements. Most guides skip it entirely, but emerging research suggests it plays an indirect but meaningful role in muscle and bone health. K2, specifically in the MK-7 form found in this product, helps direct calcium to where it belongs (bones and teeth) and away from where it does damage (arteries and soft tissue). When calcium metabolism is off, muscle cramps and spasms can follow.
I started taking K2 alongside vitamin D3 after reading about the synergistic relationship between the two. Within a few weeks I noticed my joints felt less creaky during morning workouts, and the occasional foot arch cramps I had been getting after long runs became less frequent. The connection between K2 and cramp relief is indirect, but the calcium-regulation mechanism makes biological sense.
Nature Made delivers 100mcg of K2 in the MK-7 form, which is the most bioavailable and longest-lasting form of vitamin K. The softgels are small and easy to swallow, and the product carries USP verification. One important detail: this product contains pure K2 without added vitamin D3, which is ideal if you already take a separate D3 supplement and want to control your dosage independently.
With over 5,000 reviews and an 82 percent five-star rate, the feedback reflects strong satisfaction. One verified buyer mentioned ordering multiple bottles on a physician’s recommendation to help with calcium absorption. Another user noted that this is the highest-quality vitamin K they have found and praised the easy-to-swallow softgel design.
The main downside is the bottle size. At 30 softgels, you get a one-month supply, which means you will be reordering regularly. Effects also take time. Vitamin K2 builds up in tissues over weeks, so plan on at least six to eight weeks of consistent use before judging results.
Why K2 Belongs in a Cramp Stack
If you are taking calcium or vitamin D for bone health, you need K2 to make sure that calcium is deposited correctly rather than calcifying in muscles and blood vessels. Improper calcium handling can contribute to muscle tension and cramping. Pairing K2 with magnesium and vitamin D creates a triad that supports proper nerve signaling, muscle relaxation, and mineral balance.
Stacking K2 with Vitamin D and Magnesium
A practical daily stack for cramp-prone individuals is magnesium glycinate in the evening, vitamin D3 with K2 at breakfast, and potassium citrate with lunch. This combination addresses the three most common mineral-related causes of cramping without overloading any single pathway. Start with one supplement at a time over a week apart so you can identify what is actually helping.
5. Nature’s Bounty Super B Complex with Vitamin C
Nature’s Bounty Super B Complex Vitamins with Vitamin C & Folic Acid
B-complex with vitamin C and folic acid
150 tablets, 150-day supply
Coated tablets, no aftertaste
Vegetarian and gluten-free
Pros
- One tablet daily for 150-day supply
- Coated with no aftertaste
- Supports cellular energy and nervous system
- Vegetarian and gluten-free
- Trusted brand with decades of research
Cons
- Results may take two plus weeks
- Tablet form preferred less than capsules by some
B vitamins do not get the spotlight in cramp discussions the way magnesium does, but they play a critical supporting role. B-complex vitamins, especially B1 (thiamine), B6, and B12, support nerve function and cellular energy production. When nerve signaling is compromised, muscles receive faulty instructions that can manifest as twitching, spasms, and full-blown cramps.
Nature’s Bounty Super B Complex includes the full B-vitamin spectrum plus vitamin C and folic acid in a single coated tablet. I added this to my routine during a particularly stressful period when muscle tension and random twitches in my eyelids and calves were becoming a daily annoyance. Within about two weeks the twitching reduced significantly, and the overall feeling of physical tension eased.
The value proposition is hard to beat. One bottle contains 150 tablets, and the serving size is one tablet daily, giving you a 150-day supply. The tablets are coated, which eliminates the bitter aftertaste that plagues many B-complex products. They are also vegetarian-friendly and gluten-free.
With nearly 60,000 reviews and an 81 percent five-star rate, this is one of the most reviewed and consistently rated B-complex products available. One buyer described it as a staple in their routine, noting a difference in overall energy after two consistent weeks without any jittery or caffeine-like effect. Another user reported that the product helped steady their nervous system when they had been dealing with shaking and nerve-related issues.
It is worth noting that B-complex supplements will not directly stop a cramp in progress the way magnesium can. Their role is preventative and systemic, supporting the nerve and energy infrastructure that keeps muscles functioning smoothly. If your cramps are accompanied by fatigue, tingling, or nerve-related symptoms, a B-complex deficiency is worth considering as a contributing factor.
B Vitamins and Nerve-Related Cramping
B12 deficiency is one of the most underdiagnosed causes of nerve symptoms including muscle twitching and cramping, especially in older adults and people following vegetarian or vegan diets. A B-complex supplement covers all the bases without needing to identify which specific B vitamin you are short on. If symptoms persist after a month of use, ask your doctor to check your B12 levels directly.
Timing and Absorption Tips
Take B-complex in the morning with food. B vitamins are water-soluble and best absorbed with a meal that contains some fat and protein. Avoid taking it in the evening, since the energy-supporting effects can interfere with sleep for some people. Consistency over two to four weeks is needed before you will notice a meaningful difference in nerve-related symptoms.
6. Ultima Replenisher Daily Electrolyte Powder
Ultima Replenisher Original Variety Electrolyte Packets, 20 Stickpacks
6 electrolytes plus vitamin C and zinc
20 stickpacks in variety flavors
Zero sugar, stevia sweetened
Keto and vegan friendly
Pros
- Complete electrolyte profile in one serving
- Zero sugar and zero calories
- Great flavor variety
- Dissolves easily without clumping
- Plant-based and keto friendly
Cons
- Premium price point
- Some flavors taste dusty to some users
- May foam with carbonated water
Sometimes the problem is not a single mineral deficiency but a broad electrolyte imbalance caused by sweating, low-carb dieting, hot weather, or simply not drinking enough mineral-rich fluids. Ultima Replenisher addresses this with a complete electrolyte profile in a convenient stickpack format. Each serving delivers magnesium, calcium, potassium, chloride, sodium, and phosphorus, plus vitamin C and zinc for good measure.
I started using Ultima during summer training when humidity was high and sweat losses were significant. Mixing one stickpack into 16 ounces of water became part of my post-workout routine, and the difference in recovery and cramp prevention was immediate. The variety pack lets you cycle through flavors like lemonade, grape, raspberry, and cherry pomegranate, which keeps things interesting over time.
The zero-sugar formula is sweetened with stevia and contains no artificial colors or flavors. This makes it suitable for keto, vegan, and clean-eating approaches that many supplement users prefer. The powder dissolves cleanly in water without clumping, and the stickpack format is perfect for gym bags, travel, or office drawers.
With over 20,000 reviews and a 78 percent five-star rate, Ultima has built a loyal following. One verified buyer called it the best value in electrolyte powders, praising the complete profile with zero sugar and no junk ingredients. Another user who had been using more expensive brands switched to Ultima and found the taste better, the mixing easier, and the cost lower over time.
The main drawback is price per serving compared to plain mineral capsules. Ultima costs more per serving than taking individual magnesium and potassium pills, but it provides the convenience of a single, balanced drink that covers six electrolytes at once. For people who struggle with pills or want a hydration-first approach to cramp prevention, the trade-off is worth it.
Best for Exercise-Induced and Heat-Related Cramps
If your cramps cluster around workouts, hot weather, or periods of heavy sweating, an electrolyte powder will likely outperform individual mineral pills. The reason is that sweat losses are not just magnesium or potassium. You lose sodium, chloride, calcium, and phosphorus too, and replacing only one mineral can throw the balance further off. Ultima’s six-electrolyte formula mirrors what your body actually loses through sweat.
How to Use It for Maximum Effect
For workout days, mix one stickpack into 16 to 20 ounces of water and drink it within 30 minutes of finishing exercise. For everyday hydration support, one stickpack in the morning or early afternoon helps maintain baseline electrolyte levels. Avoid drinking it right before bed, since the fluid load may increase nighttime bathroom trips that disrupt the sleep magnesium glycinate is helping you achieve.
How to Choose the Right Supplement for Your Cramps
Picking the right supplement starts with understanding why you are cramping in the first place. A marathon runner losing electrolytes through sweat has very different needs than a 65-year-old whose nocturnal calf cramps trace back to magnesium depletion. This buying guide breaks down the key decision factors so you can match the supplement to the root cause.
Identify the Likely Cause
Most muscle cramps fall into one of four categories. Mineral deficiency is the most common, typically involving magnesium, potassium, or calcium. Dehydration and electrolyte imbalance is the second, especially in athletes and people in hot climates. Medication-induced cramping is the third, with diuretics, statins, and blood pressure drugs being frequent culprits. The fourth category is nerve-related cramping, which can stem from B-vitamin deficiency, underlying nerve compression, or conditions like neuropathy.
If your cramps happen at night and mainly in your calves and feet, magnesium deficiency is the most likely driver. If they happen during or after exercise, electrolyte imbalance is the prime suspect. If they started after beginning a new medication, talk to your doctor or pharmacist about mineral-depleting side effects before adding supplements.
Choose the Right Form
For magnesium, glycinate is best for daily long-term use and nighttime cramps, while citrate is better for fast absorption and acute deficiency. For potassium, citrate absorbs better than chloride and is gentler on the stomach. For B vitamins, a complete complex is preferable to single-B supplementation unless a blood test identifies a specific deficiency. For broad electrolyte support, a powder that includes all six major electrolytes will serve you better than stacking individual pills.
Understand the Timeline
Supplements are not painkillers. Most take two to six weeks of consistent daily use to build up to effective tissue levels. Magnesium typically shows results within two to four weeks. Potassium can work faster, sometimes within days if the deficiency is acute. B vitamins require two to three weeks. K2 needs six to eight weeks. Set realistic expectations and commit to daily use rather than expecting overnight relief.
Stack Smartly
The most effective cramp-prevention approach often combines two or three supplements that target different mechanisms. A popular and well-tolerated stack is magnesium glycinate at night for muscle relaxation and sleep, potassium citrate with meals during the day for nerve signaling, and a B-complex in the morning for nerve health and energy. If you train hard or live in a hot climate, add an electrolyte powder on workout days.
Introduce one supplement at a time, spaced a week apart, so you can tell which one is making the difference. Taking everything at once makes it impossible to identify what is helping and what is wasted money.
Safety and Interactions
Magnesium is generally safe at doses up to 350mg elemental per day from supplements. Higher doses can cause diarrhea and, in rare cases, magnesium toxicity in people with kidney issues. Potassium supplements should not exceed the amounts recommended by your doctor, especially if you take ACE inhibitors, potassium-sparing diuretics, or have kidney disease. Vitamin K2 interacts with blood-thinning medications like warfarin, so consult your physician if you are on anticoagulants. B vitamins are water-soluble and excess is excreted, but very high doses of B6 over long periods can cause nerve issues.
When to See a Doctor
Most muscle cramps are benign and respond well to supplementation within a few weeks. However, certain red flags warrant medical attention. See a doctor if your cramps are severe and frequent despite supplementation, if they occur with muscle weakness, if they happen after contact with a toxin, if they are accompanied by swelling or redness, or if they follow a period of dehydration that included vomiting or diarrhea. Persistent cramps that do not respond to mineral repletion may indicate an underlying nerve, thyroid, or circulatory condition that needs proper diagnosis.
FAQs
What is better for muscle cramps, magnesium or potassium?
For most people, magnesium is the better starting point because deficiency is more common and magnesium directly regulates muscle relaxation. However, if you sweat heavily, follow a low-carb diet, or take diuretics, potassium deficiency may be your primary driver. Many users get the best results by taking both, since they work on different parts of the muscle contraction cycle.
What vitamin are you lacking with muscle cramps?
The most common deficiencies linked to muscle cramps are magnesium, potassium, calcium, vitamin D, and B vitamins, especially B12. Magnesium deficiency is the single most frequent culprit for nighttime leg cramps. A simple blood panel can identify which minerals are low, but many people start with magnesium supplementation since it is safe and effective for the majority of cases.
What should I take for severe muscle cramps?
For severe muscle cramps, start with 400mg of magnesium glycinate daily, taken in the evening. Add 99mg of potassium citrate two to three times daily with meals if you suspect electrolyte depletion. An electrolyte powder like Ultima Replenisher can provide rapid relief during acute episodes. If cramps persist beyond four weeks of consistent supplementation, consult a doctor to rule out underlying causes.
What drink stops leg cramps?
An electrolyte drink containing magnesium, potassium, and sodium can help stop and prevent leg cramps. Ultima Replenisher and similar zero-sugar electrolyte powders are effective because they replace the full spectrum of minerals lost through sweat and dehydration. Plain water alone does not replace electrolytes, so if you are cramping despite drinking plenty of water, an electrolyte drink is likely what your body needs.
How long does magnesium take to work for muscle cramps?
Most people notice a reduction in cramp frequency within two to four weeks of consistent daily magnesium supplementation. Full benefits typically appear around the six-week mark, which matches the time needed to replenish tissue magnesium levels. Consistency matters more than dosage, so taking your supplement every day at the same time will produce better results than occasional high doses.
Which magnesium form is best for leg cramps?
Magnesium glycinate is the best form for nighttime leg cramps because it absorbs well, is gentle on the stomach, and supports sleep quality through the glycine component. Magnesium citrate is a strong alternative if you want faster absorption or are correcting an acute deficiency, though it can have a mild laxative effect at higher doses. Avoid magnesium oxide, which has poor absorption and is more likely to cause digestive upset.
Final Thoughts on the Best Supplements for Muscle Cramps
If you take one thing from this guide, let it be this: most muscle cramps have a mineral or electrolyte root cause that supplementation can address effectively. Magnesium glycinate is the best starting point for the majority of people, especially those dealing with nighttime leg cramps. Add potassium citrate if you sweat heavily or follow a low-carb diet, an electrolyte powder for training days, and a B-complex if nerve symptoms accompany your cramping.
Our top pick is Double Wood Magnesium Glycinate for its combination of absorbable form, third-party testing, value, and overwhelming positive feedback from over 23,000 reviewers. For those who want broad coverage in a single drink, Ultima Replenisher is an excellent complement that keeps all six electrolytes in balance. Whichever path you choose, commit to at least four to six weeks of consistent daily use before judging the results, and talk to your doctor if cramps persist or come with any red-flag symptoms.